Download structure of lipids for free12/29/2023 ![]() However, the brain has a poor capacity to synthesize lipids which must be supplied from peripheral blood circulation and cross the barriers protecting the entrance of toxic molecules within the central nervous system (CNS) ( Igarashi et al., 2007 Lacombe et al., 2018). The brain is rich in lipids since it contains 24% phospholipids (PLs) and 22% cholesterol by dry matter ( Svennerholm et al., 1997). ![]() An assessment provided here is that the current knowledge of how lipids cross these barriers in humans is limited, which hence potentially restrains our capacity to intervene in and prevent neurodegenerative diseases. Implications of these processes in health and disease, particularly during aging and neurodegenerative diseases, are also addressed. In this review, the current knowledge of how lipids cross these barriers to reach the CNS is presented and discussed. ![]() Transport into and out of the central nervous system depends on two main sets of barriers: the blood-brain barrier (BBB) between peripheral blood and brain tissue and the blood-cerebrospinal fluid (CSF) barrier (BCSFB) between the blood and the CSF. However, researchers have not elucidated how n-3 PUFAs are transferred from the blood to the brain or how they relate to cognitive scores. Many prospective studies have shown that a diet enriched in omega-3 polyunsaturated fatty acids (n-3 PUFAs) can improve cognitive function during normal aging and prevent the development of neurocognitive diseases. 5Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Quebec City, QC, Canada.4Département de Médecine, Université de Sherbrooke, Sherbrooke, QC, Canada.3Centre de Recherche sur le Vieillissement, CIUSSS de l’Estrie – CHUS, Sherbrooke, QC, Canada.2Département de Biochimie et de Génomique Fonctionnelle, Université de Sherbrooke, Sherbrooke, QC, Canada.1UMR CNRS MNHN 7179 MECADEV, Brunoy, France.Fabien Pifferi 1, Benoit Laurent 2,3 and Mélanie Plourde 3,4,5*
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